Meenhard Herlyn Selected Research

Imatinib Mesylate (Gleevec)

12/2021	Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy.
7/2008	Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.

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Meenhard Herlyn Research Topics

Disease

192	Melanoma (Melanoma, Malignant) 02/2024 - 01/2002
167	Neoplasms (Cancer) 04/2024 - 01/2002
27	Neoplasm Metastasis (Metastasis) 01/2023 - 01/2002
8	Carcinogenesis 01/2021 - 01/2003
5	Inflammation (Inflammations) 01/2022 - 01/2003
5	Disease Progression 01/2021 - 01/2005
5	Esophageal Squamous Cell Carcinoma 01/2012 - 02/2007
4	Hypoxia (Hypoxemia) 12/2017 - 03/2005
3	Nevus (Nevi) 12/2018 - 09/2012
3	Genomic Instability 01/2017 - 04/2005
3	Wounds and Injuries (Trauma) 12/2012 - 09/2004
3	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2012 - 01/2002
3	Hyperplasia 01/2012 - 01/2002
2	Residual Neoplasm 01/2023 - 06/2011
2	Glioma (Gliomas) 01/2022 - 12/2021
2	Testicular Neoplasms (Testicular Cancer) 10/2020 - 05/2008
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/2019 - 12/2002

Drug/Important Bio-Agent (IBA)

39	Proteins (Proteins, Gene)FDA Link 01/2023 - 06/2002
27	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2023 - 02/2003
15	Cadherins (E-Cadherin)IBA 01/2018 - 01/2004
14	Mitogen-Activated Protein KinasesIBA 07/2016 - 01/2002
12	Phosphotransferases (Kinase)IBA 11/2023 - 12/2002
12	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2017 - 02/2002
11	Immune Checkpoint InhibitorsIBA 01/2022 - 03/2016
10	Biomarkers (Surrogate Marker)IBA 04/2024 - 12/2007
10	VemurafenibIBA 05/2019 - 10/2010
9	LigandsIBA 01/2022 - 09/2003
8	Transcription Factors (Transcription Factor)IBA 11/2023 - 11/2003
8	CollagenIBA 06/2023 - 05/2005
8	Cyclin D1IBA 11/2013 - 06/2002
7	RNA (Ribonucleic Acid)IBA 10/2023 - 04/2017
7	AntigensIBA 01/2023 - 06/2003
7	CytokinesIBA 01/2018 - 02/2002
6	DNA (Deoxyribonucleic Acid)IBA 08/2023 - 12/2002
5	Programmed Cell Death 1 ReceptorIBA 10/2023 - 01/2015
5	IntegrinsIBA 02/2023 - 06/2005
5	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 01/2017 - 04/2003
5	Protein Kinases (Protein Kinase)IBA 12/2016 - 10/2002
4	AntibodiesIBA 06/2023 - 01/2015
4	EnzymesIBA 01/2023 - 09/2003
4	Fatty Acids (Saturated Fatty Acids)IBA 01/2023 - 11/2017
4	ChemokinesIBA 12/2021 - 05/2003
4	Protein Isoforms (Isoforms)IBA 12/2019 - 12/2010
4	Complementary DNA (cDNA)IBA 05/2016 - 01/2002
4	Interleukin-8 (Interleukin 8)IBA 05/2016 - 02/2002
3	Hematoxylin (Haematoxylon)IBA 04/2024 - 08/2006
3	Eosine Yellowish-(YS) (Eosin)IBA 04/2024 - 08/2006
3	PlasticsIBA 01/2023 - 12/2005
3	Proto-Oncogene Proteins B-rafIBA 11/2022 - 02/2003
3	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2022 - 07/2004
3	ProdrugsIBA 01/2022 - 12/2017
3	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2021 - 05/2006
3	Small Interfering RNA (siRNA)IBA 11/2020 - 12/2012
3	LipidsIBA 01/2020 - 05/2008
3	Sorafenib (BAY 43-9006)FDA Link 01/2018 - 11/2005
3	Adenosine Triphosphate (ATP)IBA 07/2017 - 06/2012
3	PLX 4720IBA 06/2017 - 02/2008
3	MicroRNAs (MicroRNA)IBA 04/2017 - 11/2011
3	Insulin-Like Growth Factor I (IGF-1)IBA 01/2017 - 02/2002
3	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 07/2016 - 09/2003
3	ErbB Receptors (EGF Receptor)IBA 05/2016 - 01/2003
3	Chemokine ReceptorsIBA 09/2015 - 05/2005
3	Peptides (Polypeptides)IBA 01/2015 - 08/2005
3	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 11/2013 - 09/2007
3	Cisplatin (Platino)FDA LinkGeneric 06/2013 - 09/2003
3	MAP Kinase Kinase Kinases (MAP Kinase Kinase Kinase)IBA 02/2012 - 05/2006
3	Histones (Histone)IBA 10/2010 - 04/2003
3	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 06/2010 - 11/2005
3	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2010 - 04/2006
2	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 01/2024 - 01/2018
2	histone H3 trimethyl Lys4IBA 11/2023 - 02/2018
2	matrigelIBA 06/2023 - 01/2014
2	Neoplasm Antigens (Tumor Antigens)IBA 01/2023 - 06/2003
2	Inhibitor of Apoptosis ProteinsIBA 01/2023 - 04/2013
2	CalciumIBA 11/2022 - 01/2016
2	Therapeutic UsesIBA 01/2022 - 12/2017
2	Temozolomide (Temodar)FDA LinkGeneric 01/2022 - 12/2021
2	Indicators and Reagents (Reagents)IBA 01/2022 - 01/2012
2	Monophenol Monooxygenase (Tyrosinase)IBA 01/2022 - 04/2017
2	alpha-2'-deoxythioguanosineIBA 12/2021 - 10/2018
2	NucleosidesIBA 12/2021 - 10/2018
2	Imatinib Mesylate (Gleevec)FDA Link 12/2021 - 07/2008
2	Sunitinib (Sutent)FDA Link 12/2021 - 12/2017
2	Membrane Proteins (Integral Membrane Proteins)IBA 11/2021 - 10/2002
2	Mechanistic Target of Rapamycin Complex 1IBA 01/2021 - 11/2017
2	VimentinIBA 01/2020 - 06/2011
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 12/2019 - 11/2017
2	Endoplasmic Reticulum Chaperone BiPIBA 01/2019 - 03/2014
2	Telomerase (Telomerase Reverse Transcriptase)IBA 10/2018 - 11/2007
2	Drug CombinationsIBA 01/2018 - 01/2008
2	ChromatinIBA 01/2018 - 03/2015
2	CateninsIBA 11/2017 - 09/2012
2	CyclinsIBA 01/2017 - 07/2008
2	Caspase 3 (Caspase-3)IBA 09/2015 - 09/2003
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2015 - 01/2003

Therapy/Procedure

126	Therapeutics 04/2024 - 10/2002
21	Immunotherapy 11/2023 - 07/2002
9	Drug Therapy (Chemotherapy) 02/2020 - 11/2005
2	Heterologous Transplantation (Xenotransplantation) 01/2019 - 03/2008
2	Artificial Skin 09/2016 - 06/2009